Synthesis and in vitro antitumor activity of 1, 3, 4-oxadiazole derivatives based on benzisoselenazolone

ZH Luo, SY He, BQ Chen, YP Shi, YM Liu…

Index: Luo, Zhen-Hua; He, Shuang-Yan; Chen, Bao-Quan; Shi, Yan-Ping; Liu, Yu-Ming; Li, Cai-Wen; Wang, Qiu-Sheng Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 7 p. 887 - 891

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Citation Number: 13

Abstract

A series of novel 1, 3, 4-oxadiazole derivatives based on benzisoselenazolone has been prepared and tested for antiproliferative activity in vitro against the cells of human cancer cell lines: SSMC-7721 (human liver cancer cell), MCF-7 (human breast cancer cell) and A549 (human lung cancer cell). All the compounds obtained exhibited antiproliferative activity and showed selective cytotoxicity against different cancer cells. Compounds 7d and 7i showed ...