The Journal of Organic Chemistry

Total synthesis of L, L-isodityrosine and isodityrosine-derived agents: K-13, OF4949-III, and OF4949-IV

DL Boger, D Yohannes

Index: Boger, Dale L.; Yohannes, Daniel Journal of Organic Chemistry, 1990 , vol. 55, # 24 p. 6000 - 6017

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Citation Number: 81

Abstract

Full details of the development of reaction conditions for implementation of an activated Ullmann condensation reaction that may be conducted without amino acid racemization and that have proven suitable for incorporation of the selectively protected catechol of functionalized L-Dopa derivatives are described. The application of this procedure in the total synthesis of L, L-iscdityrosine (15), K-13 (I), and OF4949-III/OF4949-IV (4/5) is ...

~99%

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Development of tripeptidyl farnesyltransferase inhibitors

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