Synthesis of 7??Sulfamoyl??substituted 2??Oxo??2, 3, 4, 5??tetrahydro??1 H??benzo [b] azepines

MV Dorogov, SA Ivanovsky, MY Khakhina…

Index: Dorogov, Mikhail V.; Ivanovsky, Sergey A.; Khakhina, Maria Y.; Kravchenko, Dmitry V.; Tkachenko, Sergey E.; Ivachtchenko, Alexandre V. Synthetic Communications, 2006 , vol. 36, # 23 p. 3525 - 3535

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Abstract

Abstract Sulfochlorination of 2?螫?xo??2, 3, 4, 5??tetrahydro??1 H??benzo [b] azepine led to regioselective formation of the corresponding 7??chlorosulfonyl derivative. Starting from this reagent, a large number of substituted 2??oxo??7??sulfamoyl??2, 3, 4, 5??tetrahydro??1 H??benzo [b] azepines were obtained. This approach is amenable to combinatorial production of the title compounds, which possess promising therapeutic potential.