Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides†

…, S Fukayama, I Goljer, G Krishnamurthy…

Index: Moore, William J.; Kern, Jeffrey C.; Bhat, Ramesh; Commons, Thomas J.; Fukayama, Shoichi; Goljer, Igor; Krishnamurthy, Girija; Magolda, Ronald L.; Nogle, Lisa; Pitts, Keith; Stauffer, Barb; Trybulski, Eugene J.; Welmaker, Gregory S.; Wilson, Matthew; Bodine, Peter V. N. Journal of Medicinal Chemistry, 2009 , vol. 52, # 1 p. 105 - 116

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Citation Number: 44

Abstract

The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-related disorders. Details of the structure− activity relationships and biological activity from the first structural class of this ...