Discovery of 2-[1-(4-chlorophenyl) cyclopropyl]-3-hydroxy-8-(trifluoromethyl) quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved …

A Huang, A Moretto, K Janz, M Lowe…

Index: Fedorynski, Michal; Jonczyk, Andrzej Organic Preparations and Procedures International, 1995 , vol. 27, # 3 p. 355 - 359

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Citation Number: 15

Abstract

... Volume: Page: ... 2010, 53 (16), pp 6003–6017. DOI: 10.1021/jm9013696. Publication Date (Web): July 27, 2010. Copyright ... However, we were able to prepare it via ortho-lithiation of the BOC-protected aniline and reaction of the aryllithium species with diethyl ...