Structure− activity relationships for a novel series of citalopram (1-(3-(dimethylamino) propyl)-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile) analogues …

P Zhang, G Cyriac, T Kopajtic, Y Zhao…

Index: Zhang, Peng; Cyriac, George; Kopajtic, Theresa; Zhao, Yongfang; Javitch, Jonathan A.; Katz, Jonathan L.; Newman, Amy Hauck Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6112 - 6121

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Citation Number: 23

Abstract

(±)-Citalopram (1, 1-(3-(dimethylamino) propyl)-1-(4-fluorophenyl)-1, 3- dihydroisobenzofuran-5-carbonitrile), and its eutomer, escitalopram (S-(+)-1) are selective serotonin reuptake inhibitors (SSRIs) that are used clinically to treat anxiety and depression. To further explore structure− activity relationships at the serotonin transporter (SERT), a series of (±)-4-and 5-substituted citalopram analogues were designed, synthesized, and ...