Synthesis of tritium??labeled levetiracetam ((2S)??2??(2??oxopyrrolidin??1??yl) butanamide) with high specific activity

S Hildenbrand, Y Baqi, CE Müller

Index: Hildenbrand, Simone; Baqi, Younis; Mueller, Christa E. Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 1 p. 48 - 51

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Citation Number: 2

Abstract

Levetiracetam (1;(2S)-2-(2-oxopyrrolidin-1-yl) butanamide, KeppraW) is a pyrrolidone drug widely used in antiepileptic therapy. Since its approval in the USA in 1999, it has become one of the most successful therapeutics of the newer classes of antiepileptic drugs (AED). Several beneficial properties including potent antiepileptogenic effects, absence of severe adverse effects, and a low potential for drug interactions1, 2 have indicated that ...