Tetrahedron letters

Diastereoselective and enantioselective microbial reduction of cyclic alpha-alkyl beta-ketoesters

D Buisson, R Azerad

Index: Buisson, Didier; Azerad, Robert Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2631 - 2634

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Citation Number: 77

Abstract

Abstract The reduction of racemic cyclopenta-and cyclohexanone 2-carboxyesters by various yeast and mould strains was shown to produce different amounts of isomeric beta- hydroxyesters with predominant (1S) stereochemistry. With several strains, only one optically pure Full-size image (< 1 K)