Solid phase synthesis of a redox delivery system with the aim of targeting peptides into the brain

…, L Foucout, P Bohn, G Dupas, J Leprince…

Index: Patteux, Claudine; Foucout, Lenaig; Bohn, Pierre; Dupas, Georges; Leprince, Jerome; Tonon, Marie-Christine; Dehouck, Benedicte; Marsais, Francis; Papamicael, Cyril; Levacher, Vincent Organic and Biomolecular Chemistry, 2006 , vol. 4, # 5 p. 817 - 825

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Citation Number: 13

Abstract

A solid phase approach for the preparation of peptides attached to a redox chemical delivery system derived from stable annulated NADH models is reported. The synthesis starts with the grafting on a Merrifield resin of quinoline 4b, precursor of the redox carrier. From the resulting quinoline supported resin 4d, the stepwise SPPS of both octapeptide OP (RPGLLDLK) and octadecaneuropeptide ODN (QATVGDVNTDRPGLLDLK), two ...