Abstract A synthetic route was developed for the preparation of deuterated mevalonolactones. Using low-cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6, 6, 6-2 H 3] mevalonolactone,[4, 4, 6, 6, 6-2 H 5] mevalonolactone,[5, 5-2 H 2] mevalonolactone,[5, 5, ...
