e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
A new synthesis of aryl hetaryl ketones via SRN1 reactions of halogenated heterocycles with potassiophenylacetonitrile followed by phase??transfer catalyzed …
CKF Hermann, YP Sachdeva…
Index: Hermann, Christine K. F.; Sachdeva, Yesh P.; Wolfe, James F. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1061 - 1065
Abstract Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.
[Carver, David R.; Greenwood, Thomas D.; Hubbard, James S.; Komin, Andrew P.; Sachdeva, Yesh P.; Wolfe, James F. Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1180 - 1185]
