Synthesis, Enzymic, and NMR Studies of Novel Sialoside Probes: Unprecedented, Selective Neuraminidase Hydrolysis of and Inhibition by C-6-(methyl)-Gal …

…, S Neira, F Davidson, JO Duus, K Bock

Index: Sabesan, Subramaniam; Neira, Susana; Davidson, Fred; Duus, Jens .; Bock, Klaus Journal of the American Chemical Society, 1994 , vol. 116, # 5 p. 1616 - 1634

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Citation Number: 53

Abstract

Abstract: We report here the synthesis of sialoside analogs, namely, a~ NeuAc (2-6)(6-Me, R)@~ Gal-OR'(R isomer, tg rotamer analog) and a~ NeuAc (2-6)(6-MeS)@~ Gal-OR~(S isomer, gt rotamer analog, R1= CHZCHzSiMe3 or H) and the corresponding sulfur linked thiosialosides useful for the determination of carbohydrate structural requirements in neuraminidase hydrolysis and for the design of neuraminidase inhibitors. The purpose of ...