[11 C] Carbon monoxide in the palladium-mediated synthesis of 11 C-labelled ketones

P Lidström, T Kihlberg, B Långström

Index: Lidstroem, Pelle; Kihlberg, Tor; Langstrom, Bengt Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 18 p. 2701 - 2706

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Citation Number: 47

Abstract

[11C] Carbon monoxide has been used in the palladium-mediated synthesis of [carbonyl- 11C] ketones. Methyl iodide, vinylic and arylic halides and trifluoromethanesulfonates (triflates) have been coupled with tin reagents with insertion of [11C] carbon monoxide at very low concentrations (10–100 nmol [11C] CO in a total volume of 10 ml). The labelled products are obtained in 36–62% isolated decay-corrected radiochemical yields within 30 ...