e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogs
…, DR Morton, DC Peterson, EE Nishizawa…
Index: Bundy, Gordon L.; Morton, D. R.; Peterson, D. C.; Nishizawa, E. E.; Miller, W. L. Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 790 - 799
Although the biological significance of the PGDs was not fully appreciated at first: particularly PGD, is a potent inhibitor of human platelet aggregation (about 10 times as active as PGE1). 5@ We report herein the synthesis and biological evaluation of a series of PGD analogues designed to determine what portions of the PGD structure are the most critical for the observed antiaggregatory activity. Chemistry. Of the several PGD syntheses a~ ailable,~~ ...
