Stereospecific synthesis of threo-and erythro-β-hydroxyglutamic acid during kutzneride biosynthesis

M Strieker, EM Nolan, CT Walsh…

Index: Strieker, Matthias; Nolan, Elizabeth M.; Walsh, Christopher T.; Marahiel, Mohamed A. Journal of the American Chemical Society, 2009 , vol. 131, # 37 p. 13523 - 13530

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Citation Number: 37

Abstract

The antifungal and antimicrobial kutznerides, hexadepsipeptides composed of one α- hydroxy acid and five nonproteinogenic amino acids, are remarkable examples of the structural diversity found in nonribosomally produced natural products. They contain d-3- hydroxyglutamic acid, which is found in the threo and erythro isomers in mature kutznerides. In this study, two putative nonheme iron oxygenase enzymes, KtzO and KtzP, were ...