A New Scalable Route to 4-(2-Hydroxyethyl)-1, 3-dihydro-2 H-indol-2-one: A Key Intermediate for Ropinirole Hydrochloride

H Chen, Y Chen, L Yuan, Q Zou

Index: Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9

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Abstract

... After simple operation, 13 was crystallized as a white solid with 99% purity in 71% total yield from 2, when solvent was concentrated to 10% of ... t, J = 6.8 Hz, 2H), 3.80 (q, J = 6.4 Hz, 2H), 7.24 (t, J = 7.6 Hz, 1H), 7.41 (d, J = 7.6 Hz, 1H), 7.59 (d, J = 8.0 Hz, 1H); 13 C NMR (CDCl ...