Process development and pilot plant synthesis of methyl 2-bromo-6-chlorobenzoate

MR Hickey, SP Allwein, TD Nelson…

Index: Organic Process Research and Development, , vol. 9, # 6 p. 764 - 767

Full Text: HTML

Citation Number: 16

Abstract

... After an extractive workup with MTBE and THF, the solvents in the organic stream were switched to 2-propanol. ... Scheme 4. Through process to synthesize 1. ... Both the aqueous phase and the water wash contained <1% ester 1. The organics from the first batch were stored and ...