Nitrogen-containing organosilicon compounds. CXXII. Synthesis and pharmacological studies of trialkylsilylalkylaminoethyl dicarboxylate methiodides

…, ID Segal, MM Veveris, LN Khokhlova

Index: Lukevits, E. Ya.; Segal, I. D.; Veveris, M. M.; Khokhlova, L. N. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 11 p. 754 - 758 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 11 p. 1314 - 1318

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Abstract

The organosilicon aminoalcohols Ia-g were synthesized from trialkyl (chloroalkyl) silanes and N-methylaminoethanol in the presence of triethylamine in a butanol medium. The products of reaction of trialkyl (2-hydroxyethylaminoalkyl) silanes with succinic, adipic, suberic, azelaic, and sebacic chlorides were treated with methyl iodide to obtain the methiodides III-VII.