General??base catalysed hydrolysis and nucleophilic substitution of activated amides in aqueous solutions

…, MJ Blandamer, JBFN Engberts

Index: Buurma, Niklaas J.; Blandamer, Michael J.; Engberts, Jan B.F.N. Journal of Physical Organic Chemistry, 2003 , vol. 16, # 8 p. 438 - 449

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Citation Number: 10

Abstract

Abstract The reactivity of 1-benzoyl-3-phenyl-1, 2, 4-triazole (1a) was studied in the presence of a range of weak bases in aqueous solution. A change in mechanism is observed from general-base catalysed hydrolysis to nucleophilic substitution and general- base catalysed nucleophilic substitution. A slight tendency is also observed for the more hydrophobic general bases to show higher reactivity towards 1a. Aspartame is an effective ...