Israel Journal of Chemistry

The Chemistry of Cyclic Hydrazides. IX. The Synthesis and Alkylation of 1, 2??Disubstituted??Perhydropyridazine??3, 6??Diones

H Feuer, EP Rosenquist, F Brown

Index: Feuer,H. et al. Israel Journal of Chemistry, 1968 , vol. 6, p. 587 - 602

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Citation Number: 5

Abstract

Abstract The synthesis of 1, 2-disubstituted perhydropyridazine-3, 6-diones in high yield is described. The reaction of succinic anhydride and 1, 2-dialkylhydrazines leads to N, N′- dialkyl-3-carboxypropionhydrazides which are converted to 1, 2-dialkylperhydropyridazine- 3, 6-diones in refluxing xylene or polyphosphoric acid. The reaction of 1, 2-diarylhydrazines with 3-carbomethoxypropionyl chloride and hydrolysis of the resulting N, N′-diaryl-3- ...