Synthesis of tert-butyl 6-oxo-2-azaspiro [3.3] heptane-2-carboxylate

MJ Meyers, I Muizebelt, J Wiltenburg, DL Brown…

Index: Meyers, Marvin J.; Muizebelt, Inouk; Van Wiltenburg, Jim; Brown, David L.; Thorarensen, Atli Organic Letters, 2009 , vol. 11, # 16 p. 3523 - 3525

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Citation Number: 17

Abstract

Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6- oxo-2-azaspiro [3.3] heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.