Mono??and Disubstituted N, N??Dialkylcyclopropylamines from Dialkylformamides via Ligand??Exchanged Titanium–Alkene Complexes

…, V Chaplinski, M Kordes, AI Savchenko…

Index: De Meijere, Armin; Williams, Craig M.; Kourdioukov, Alexandre; Sviridov, Sergei V.; Chaplinski, Vladimir; Kordes, Markus; Savchenko, Andrei I.; Stratmann, Christian; Noltemeyer, Mathias Chemistry - A European Journal, 2002 , vol. 8, # 16 p. 3789 - 3801

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Citation Number: 59

Abstract

Abstract Dibenzylformamide was treated with cyclohexylmagnesium bromide in the presence of either titanium tetraisopropoxide or methyltitanium triisopropoxide and a variety of cyclic and acyclic alkenes and alkadienes to give new mono-and disubstituted as well as bicyclic dialkylcyclopropylamines (Tables 1–3, 2, 3) in yields ranging from 18 to 90%(in most cases around 55%). 3-Benzyl-6-(N, N-dibenzylamino)-3-azabicyclo [3.1. 0] hexane (10 a) ...