A New Protocol for the Consecutive α??and β??Activation of Propiolates towards Electrophiles, Involving Conjugate Addition of Tertiary Amines and Intramolecular Silyl …

Y Matsuya, K Hayashi, H Nemoto

Index: Matsuya, Yuji; Hayashi, Kousuke; Nemoto, Hideo Chemistry - A European Journal, 2005 , vol. 11, # 18 p. 5408 - 5418

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Citation Number: 14

Abstract

Abstract Herein, we present a novel approach for the consecutive α-and β-activation of conjugated alkynes and demonstrate the application of this methodology towards the C [BOND] C bond-forming reactions of propiolates. This new concept is based on the 1, 4- addition of a tertiary amine to a conjugated alkyne, followed by an aldol-type addition to an aldehyde and subsequent intramolecular silyl migration. This sequential process is ...