Side chain protected N α-fluorenylmethoxycarbonylamino-acids for solid phase peptide synthesis. N α-Fluorenylmethoxycarbonyl-NG-4-methoxy-2, 3, 6- …

E Atherton, RC Sheppard, JD Wade

Index: Atherton, Eric; Sheppard, Robert C.; Wade, John D. Journal of the Chemical Society, Chemical Communications, 1983 , # 19 p. 1060 - 1062

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Citation Number: 18

Abstract

The preparation and use in solid phase synthesis of Na-fluorenylmethoxycarbonyl-N~-4-methoxy -2,3,6- trimethyl benzenesu Iphonyl- L-arginine is described. ... Protection of the guanidine side chain of arginine derivatives presents a continuing problem in both classical (solution) and solid phase peptide synthesis. In the latter, the introductionlJ of N "-fluorenylmethoxycarbonyl (Fmoc) amino-acids3 as alternatives to the customary t-butoxycarbonyl (Boc) deriva- tives ...