Letters in Drug Design & Discovery

Synthesis and preliminary biological activity of some new pyrazole derivatives as acyclonucleoside analogues

S Radi, S Salhi, A Radi

Index: Radi, Smaail; Salhi, Souad; Radi, Amal Letters in Drug Design and Discovery, 2010 , vol. 7, # 1 p. 27 - 30

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Citation Number: 28

Abstract

Some novel pyrazole acyclonucleosides were prepared through binding of pyrazole-3, 5- substituted derivatives with acyclic substituents mimetizing individual fragments of the ribose ring such as: 1-[(2-hydroxyethoxy) methyl], 1-[4-(hydroxybutyl)], 1-[3-(hydroxypropyl)] and 1- [(2-hydroxyethyl amino) methyl]. Their syntheses were performed from easily accessible starting materials. The prepared compounds were evaluated for their antibacterial activity. ...