Derivatives of 4 (5) substituted-1, 2, 3-triazol-5 (4)-carboxylic acids synthesis and antitumor activity

MP Nemeryuk, AL Sedov, NA Ryabokon'…

Index: Nemeryuk, M. P.; Sedov, A. L.; Ryabokon, N. A.; Ershova, Yu. A.; Sokolova, A. S.; et al. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 6 p. 406 - 410 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 6 p. 23 - 25

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Abstract

It was established that the structure of these derivatives of 1, 2, 3-triazole depends not only on the character of the substituent in the starting 5-aminopyrimidine but also on the conditions for carrying out the reaction. Thus in AcOH the formation of a 1, 2, 3-triazole carrying an N-formylcarboxamide substJtuent (IIr-u, w; Table i) is often observed. To obtain 1, 2, 3-triazoles substituted in position 4 (5) with an amidine, ester or cyano group, ...