(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The …

…, J Senn-Bilfinger, WA Simon, U Krueger…

Index: Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057

Full Text: HTML

Citation Number: 77

Abstract

[(Pyridylmethyl) sulf'iiyl] benzimidazoles 1 (PSBs) are a class of highly potent antisecretory (H+, K+)-ATPase inhibitors which need to be activated by acid to form their active principle, the cyclic sulfenamide 4. Selective inhibitors of the (H+, K+)-ATPase in vivo give rise to the nonselective thiophile 4 solely at low pH, thus avoiding interaction with other thiol groups in the body. The propensity to undergo the acid-catalyzed transformation is dependent on ...

 Related Synthetic Route
(4-methoxy-5-methylpyridin-2-yl)methanol Structure

94452-65-0

(4-methoxy-5-me...

~%

2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride Structure

94452-59-2

2-(chloromethyl...

N/A Structure

97967-00-5

N/A

~86%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

2,3-Dimethyl-4-nitropyridine 1-oxide Structure

37699-43-7

2,3-Dimethyl-4-...

~%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

(4-Methoxy-3-methylpyridin-2-yl)methanol Structure

86604-77-5

(4-Methoxy-3-me...

~%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

4-methoxy-2,3-dimethyl-1-oxidopyridin-1-ium Structure

102625-96-7

4-methoxy-2,3-d...

~%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

2,2-difluoro-6-mercapto-5H-[1,3]dioxolo-[4,5-f]benzimidazole Structure

97967-01-6

2,2-difluoro-6-...

~%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

2-(Chloromethyl)-4-methoxy-3-methylpyridine hydrochloride Structure

86604-74-2

2-(Chloromethyl...

~%

2,2-difluoro-6-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole Structure

97966-86-4

2,2-difluoro-6-...

2-Picoline 1-oxide Structure

931-19-1

2-Picoline 1-oxide

~%

2-(CHLOROMETHYL)-4-METHOXYPYRIDINE HYDROCHLORIDE Structure

62734-08-1

2-(CHLOROMETHYL...

2-acetoxymethyl-4,5-dimethoxypyridine Structure

105552-55-4

2-acetoxymethyl...

~%

(4,5-Dimethoxy-pyridin-2-yl)-methanol Structure

62885-49-8

(4,5-Dimethoxy-...

4,5-dimethoxy-2-methylpyridine 1-oxide Structure

102625-90-1

4,5-dimethoxy-2...

~%

(4,5-Dimethoxy-pyridin-2-yl)-methanol Structure

62885-49-8

(4,5-Dimethoxy-...

5-methoxy-2-methyl-4-nitro-pyridine-1-oxide Structure

102625-91-2

5-methoxy-2-met...

~%

(4,5-Dimethoxy-pyridin-2-yl)-methanol Structure

62885-49-8

(4,5-Dimethoxy-...

2,3-Dimethylpyridine-N-oxide Structure

22710-07-2

2,3-Dimethylpyr...

~%

3-methoxy-2-methyl-6-nitropyridine 1-oxide Structure

35392-67-7

3-methoxy-2-met...

2,3-Dimethyl-4-nitropyridine 1-oxide Structure

37699-43-7

2,3-Dimethyl-4-...

Ethanoic anhydride Structure

108-24-7

Ethanoic anhydride

4-Methoxy-2,3,5-trimethylpyridine N-oxide Structure

86604-80-0

4-Methoxy-2,3,5...

~%

2-(ACETOXYMETHYL)-4-METHOXY-3,5-DIMETHYLPYRIDINE Structure

91219-90-8

2-(ACETOXYMETHY...

Methanol Structure

67-56-1

Methanol

3-methoxy-2-methyl-4-nitropyridine 1-oxide Structure

15931-25-6

3-methoxy-2-met...

~89%

3,4-dimethoxy-2-methylpyridine n-oxide Structure

72830-07-0

3,4-dimethoxy-2...

Methanol Structure

67-56-1

Methanol

4-Chloro-3-methoxy-2-methylpyridine 1-oxide Structure

122307-41-9

4-Chloro-3-meth...

~90%

3,4-dimethoxy-2-methylpyridine n-oxide Structure

72830-07-0

3,4-dimethoxy-2...

2-[(4-methoxy-pyridin-2-yl)methylthio]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97964-15-3

2-[(4-methoxy-p...

~94%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

2-Picoline 1-oxide Structure

931-19-1

2-Picoline 1-oxide

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

(4-Methoxypyridin-2-yl)methanol Structure

16665-38-6

(4-Methoxypyrid...

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

2-METHYL-4-METHOXYPYRIDINE-N-OXIDE Structure

6890-60-4

2-METHYL-4-METH...

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

4-Nitro-2-picoline-N-oxide Structure

5470-66-6

4-Nitro-2-picol...

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

ACETIC ACID 4-METHOXY-PYRIDIN-2-YLMETHYL ESTER Structure

16665-37-5

ACETIC ACID 4-M...

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

2-(CHLOROMETHYL)-4-METHOXYPYRIDINE HYDROCHLORIDE Structure

62734-08-1

2-(CHLOROMETHYL...

~%

2-[(4-methoxypyridin-2-yl)methylsulfinyl]-6-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole Structure

97963-96-7

2-[(4-methoxypy...

Methanol Structure

67-56-1

Methanol

2,3,5-Trimethyl-4-nitropyridine 1-oxide Structure

86604-79-7

2,3,5-Trimethyl...

~%

4-Methoxy-2,3,5-trimethylpyridine N-oxide Structure

86604-80-0

4-Methoxy-2,3,5...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved