Microwave-assisted N-debenzylation of amides with triflic acid

F Rombouts, D Franken, C Martínez-Lamenca…

Index: Rombouts, Frederik; Franken, Dennis; Martinez-Lamenca, Carolina; Braeken, Mirielle; Zavattaro, Chiara; Chen, Jinsheng; Trabanco, Andres A. Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4815 - 4818

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Citation Number: 12

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A new and facile microwave-assisted protocol for the debenzylation of N-benzylamides with triflic acid has been developed. Both secondary and tertiary aliphatic or aromatic amides are obtained in moderate to good yields. ... A new and facile microwave-assisted protocol for the debenzylation of ...

 Related Synthetic Route
Structure

1097010-28-0

~55%

3-(chloromethyl)benzamide Structure

135654-16-9

3-(chloromethyl...

1-benzyl-3,4-dihydroquinolin-2-one Structure

102145-14-2

1-benzyl-3,4-di...

~83%

3,4-Dihydroquinolin-2(1H)-one Structure

553-03-7

3,4-Dihydroquin...

3-benzyl-3H-thieno[2,3-d]pyrimidin-4-one Structure

18740-32-4

3-benzyl-3H-thi...

~77%

Thieno[2,3-d]pyrimidin-4(3H)-one Structure

14080-50-3

Thieno[2,3-d]py...

1-benzylquinoxalin-2(1H)-one Structure

63536-44-7

1-benzylquinoxa...

~38%

2(1H)-Quinoxalinone Structure

1196-57-2

2(1H)-Quinoxalinone

N-benzyl-3-(dimethylamino)benzamide Structure

793730-46-8

N-benzyl-3-(dim...

~83%

3-(Dimethylamino)benzamide Structure

33225-17-1

3-(Dimethylamin...

dl-1,2-diphenyl-1,2-ethanedithiol Structure

4231-61-2

dl-1,2-diphenyl...

~69%

[1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one Structure

6969-71-7

[1,2,4]Triazolo...

N-benzyl-3-methoxybenzamide Structure

82082-48-2

N-benzyl-3-meth...

~53%

N-Benzyl-3-hydroxybenzamide Structure

15789-02-3

N-Benzyl-3-hydr...

Methyl 3-(benzylcarbamoyl)benzoate Structure

925159-45-1

Methyl 3-(benzy...

~44%

3-carbamoylbenzoic acid Structure

4481-28-1

3-carbamoylbenz...

methyl 3-carbamoylbenzoate Structure

106748-24-7

methyl 3-carbam...

2-benzyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one Structure

1246923-44-3

2-benzyl-4-phen...

~90%

3H-1,2,4-Triazol-3-one,2,4-dihydro-4-phenyl- Structure

1008-30-6

3H-1,2,4-Triazo...

N/A Structure

850631-09-3

N/A

~86%

4-methylsulfonylbenzamide Structure

4461-38-5

4-methylsulfony...

1-Benzylpiperidone Structure

4783-65-7

1-Benzylpiperidone

~77%

2-Piperidone Structure

675-20-7

2-Piperidone

1-Benzyl-3-pyrrolidinone Structure

5291-77-0

1-Benzyl-3-pyrr...

~77%

2-Pyrrolidinone Structure

616-45-5

2-Pyrrolidinone


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