Tetrahedron

Copper-catalysed intramolecular O–H addition to unactivated alkenes

LA Adrio, LS Quek, JG Taylor, KKM Hii

Index: Adrio, Luis A.; Quek, Louisa Shuyi; Taylor, Jason G.; Kuok (Mimi) Hii, King Tetrahedron, 2009 , vol. 65, # 50 p. 10334 - 10338

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Citation Number: 30

Abstract

In our earlier work, we have reported the use of Cu(OTf) 2 as a catalyst in a number of intermolecular C–O and C–N bond formations, including additions of acids, phenols and alcohols to norbornene, sulfonamides to conjugate dienes and vinylarenes, and the annulation of phenols with 1,3-dienes. 4, 4a, 4b and 4c Herein, we will report the first application of this catalyst for the intramolecular O–H additions to unactivated alkenes, leading to the formation of ...