The selective bromination of tropinone (I) has not been achieved. In 1896,\. 5'illstatter3 reported that under a variety of conditions this ketone formed a tetrabromo derivative (mp 164'), but he was unable to isolate less highly substituted products. Our attempts to effect monobromination in acetic acid solution, in the presence or absence of sodium acetate, likewise afforded only the tetrabrominated product. During the csperimentation, we ...
![2-bromo-8-methyl-8-azabicyclo[3.2.1]octan-3-one Structure](https://image.chemsrc.com/caspic/407/62251-45-0.png)