e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Cycloadditions of nitrile oxides to compounds containing two-co-ordinate phosphorus or arsenic. Kinetic and thermodynamic regioselectivity
…, YYCYL Ko, F De Sarlo, A Brandi
Index: Carrie, Robert; Ko, Y. Y. C. Yeung Lam; Sarlo, Francesco De; Brandi, Alberto Journal of the Chemical Society, Chemical Communications, 1981 , # 21 p. 1131 - 1132
Cycloaddition of p-chlorobenzonitrile oxide takes place only at the CP bond of the diazaphosphole (1) yielding one regioisomer (3), and at the CAs bond of the diaza-arsole (4) yielding the analogous regioisomer (5) as the kinetic product, the other regioisomer (6) being the thermodynamic product.
![3-(4-chlorophenyl)-7-methyl-5-phenyl-5,7a-dihydro-[1,2,3]diazarsolo[3,4-d][1,2,4]oxazarsole Structure](https://image.chemsrc.com/caspic/092/82201-28-3.png)
![6-(4-chlorophenyl)-4-methyl-2-phenyl-8-oxa-2,3,7-triaza-1-arsabicyclo[3.3.0]octa-3,6-diene Structure](https://image.chemsrc.com/caspic/130/82201-27-2.png)
![5-Acetyl-3-(4-chlorophenyl)-7-methyl-5,7a-dihydro[1,2,3]diazaphospholo[3,4-d][1,2,4]oxazaphosphole Structure](https://image.chemsrc.com/caspic/168/82201-26-1.png)