Highly Efficient and Stereoselective Radical Addition of Tertiary Amines to Electron-Deficient Alkenes− Application to the Enantioselective Synthesis of Necine …

S Bertrand, N Hoffmann, JP Pete

Index: Bertrand, Samuel; Hoffmann, Norbert; Pete, Jean-Pierre European Journal of Organic Chemistry, 2000 , # 12 p. 2227 - 2238

Full Text: HTML

Citation Number: 53

Abstract

A convenient and highly efficient method for the regio-and stereoselective addition of tertiary amines to electron-deficient alkenes has been elaborated. It is based on a radical chain reaction of α-aminyl radicals with alkenes, induced by a photoelectron transfer process between tertiary amines 2a− j and excited electron donor substituted phenyl ketones. The influence of the nature of the amino substituents and of