Journal of medicinal chemistry

Approaches to the Synthesis of 1-Deazauridine and 2'-Deoxy-1-deazauridine

MP Mertes, J Zielinski, C Pillar

Index: Mertes,M.P. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 320 - 325

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Citation Number: 35

Abstract

The synthesis of 1-deazauridine 5'-nionophosphate (la) and 2'-deoxy-l-deazauridine 5'- monophosphate (lb) requires the formation of a CC glycosyl linkage between the pyridine portion and C1 of the respective sugar. Appropriate protection of the oxygen functions of the sugar and the pyridine would permit the use of a route involving alkylation of the protected halosugar by the pyridine derivative. Successful application of this approach has been ...