Design, synthesis and biological evaluation of novel 2-[(2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-ylidene) hydrazono]-1, 3-thiazolidin-4-ones as a new class of …

R Ramachandran, M Rani, S Kabilan

Index: Ramachandran; Rani; Kabilan Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2819 - 2823

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Citation Number: 41

Abstract

New series of 2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-one thiosemicarbazones (9–16) obtained from the corresponding 2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-ones (1–8) upon cyclization with ethylbromoacetate in the presence of sodium acetate–acetic acid buffer afforded novel 2-[(2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-ylidene) hydrazono]-1, 3- thiazolidin-4-ones (17–24). The synthesized compounds have been characterized by their ...