Abstract Condensation of 2, 4-dimethoxy-5-iodo-6-carbomethoxypyrimidine (10) with copper (I) 3-tetrahydropyranyloxyprop-1-ynide (4) afforded 2, 4-dimethoxy-5-(3′- tetrahydropyranyloxyprop-1′-yn)-6-carbomethoxypyrimidine (11), which was hydrolyzed to produce 2, 4-dimethoxy-5-(3′-hydroxyprop-1′-yn)-6-carbomethoxypyrimidine (12). Oxidation of 12 with dimethyl sulfoxide-oxalyl chloride reagent gave the acetylenic ...
![methyl 2,6-dimethoxy-5-[3-(oxan-2-yloxy)prop-1-ynyl]pyrimidine-4-carboxylate Structure](https://image.chemsrc.com/caspic/400/79115-67-6.png)
