(1) proposed an antiinflammatory receptor site for this molecule, a feature of which was the presence of a cavity to accommodate the p-chlorobenzoyl substituent, which had been shown to be twisted out of plane and out of conjugation with the indole nucleus. Subsequently a number of benzophenones substituted (usually in the meta position) with an acidic group (eg, 2a8 and 2b5) have been reported to show antiinflammatory activity. It is ...