7??Deazaadenosine: Oligoribonucleotide building block synthesis and autocatalytic hydrolysis of base??modified hammerhead ribozymes

F Seela, K Mersmann, JA Grasby…

Index: Seela, Frank; Mersmann, Karin; Grasby, Jane A.; Gait, Michael J. Helvetica Chimica Acta, 1993 , vol. 76, p. 1809 - 1820

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Citation Number: 42

Abstract

Abstract A 7-deazaadenosine (= tubercidin; c 7 A; 1) building block for solid-phase oligoribonucleotide synthesis was prepared. The amino group of 1 was protected with the (dimethylamino) methylidene residue ([RIGHTWARDS ARROW] 3), and the monomethoxytrityl group was introduced at OH [BOND] C (5′)([RIGHTWARDS ARROW] 4). Protection of OH [BOND] C (2′) was carried out by silylation, showing that use of the (i-Pr ...