Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1, 3-Dihydro-2H-imidazo [4, 5-b] quinolin-2-one derivatives with enhanced aqueous solubility

…, RD Dennis, HR Roth, MJ Rosenfeld…

Index: Meanwell, Nicholas A.; Dennis, Ronald D.; Roth, Herbert R.; Rosenfeld, Michael J.; Smith, Edward C. R.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2688 - 2696

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Citation Number: 11

Abstract

Two series of 1, 3-dihydro-W-imida [4, 5b] quinolin-2-one derivatives incorporating an additional site for acid salt formation were synthesized and evaluated as inhibitors of human blood platelet CAMP phosphodiesterase (PDE) and ADP-induced platelet aggregation. The objective of this study was to identify compounds that blended potent biological activity with a eatisfactory level of aqueous solubility. From a aerie of 7-a" idazo [4, 5b] quinolin-2-onea ...