Metal??Free Catalytic Nucleophilic Substitution of Propargylic Alcohols

…, JM Álvarez??Gutiérrez, F Rodríguez

Index: Sanz, Roberto; Martinez, Alberto; Alvarez-Gutierrez, Julia M.; Rodriguez, Felix European Journal of Organic Chemistry, 2006 , # 6 p. 1383 - 1386

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Citation Number: 54

Abstract

Abstract Organic acids such as PTS efficiently catalyze direct nucleophilic substitutions of the hydroxy groups of propargylic alcohols with a large variety of carbon-and heteroatom- centered nucleophiles. Reactions can be conducted under mild conditions and in air without the need for dried solvents. Reactions on multigram scales are also possible.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)