The synthesis of γ-fluoroglutamic acid, HOOCCHFCH2CH (NH2) COOH, was achieved by two independent methods, both of which involved the Michael reaction:(1) methyl α- fluoroacrylate and diethyl acetamidomalonate gave the transesterified intermediate, which on hydrolysis produced γ-fluoroglutamic acid (31% yield);(2) ethyl α-acetamidoacrylate and diethyl fluoromalonate reacted under mild conditions to give, after hydrolysis, the required ...
