Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: Identification of sulfonamido-1, 2, 3-triazole-4, 5-dicarboxylic acid

K Lee, MJ Choi, KJ Kim, KT Lee, SG Han, YG Yu…

Index: Lee, Kijae; Pham, Van Chung; Choi, Min Ji; Kim, Kyung Ju; Lee, Kyung-Tae; Han, Seong-Gu; Yu, Yeon Gyu; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 75 - 80

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Citation Number: 10

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible prostaglandin E synthase that catalyzes the conversion of prostaglandin PGH2 to PGE2 and represents a novel target for therapeutic treatment of inflammatory disorders. It is essential to identify mPGES-1 inhibitor with novel scaffold as new hit or lead compound for the purpose of the next-generation anti-inflammatory drugs. Herein we report the discovery of sulfonamido-1, ...