Tetrahedron letters

Silica gel-supported bis-cinchona alkaloid: a chiral catalyst for the heterogeneous asymmetric desymmetrization of meso-cyclic anhydrides

YM Song, JS Choi, JW Yang, H Han

Index: Song, Yu-Mi; Choi, Jin Seok; Yang, Jung Woon; Han, Hogyu Tetrahedron Letters, 2004 , vol. 45, # 16 p. 3301 - 3304

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Citation Number: 35

Abstract

A one-pot conversion of meso-cyclic anhydrides with alcoholysis in diethyl ether using SGS- (DHQ) 2AQN, a silica gel-supported chiral catalyst, into the corresponding desymmetrized mono ester acids was achieved with enantiomeric excesses of up to 84% under mild and efficient conditions.