Abstract 3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono-and bicyclic aminopyridinols from pyridoxine hydrochloride (ie, vitamin B 6). This approach provides straightforward, scaleable access to novel, potent, molecular scaffolds ...
