March 1981 An Improved Synthesis of l-Methyl-2,5-piperazinedione Thomas D. Harris*, Timothy J. Reilly and Joseph A. DelPrincipe Department of Chemistry, SUNY Fredonia, Fredonia, NY 14063 Received September 2, 1980 ... A new synthesis of l-methyl-2,5-piperazinedione in three steps starting from sarcosine is described. This method proceeds in higher overall yield (49%) than previous methods. ... Recently, during an investigation into the chemistry of ...