Tetrahedron letters

One-pot synthesis of 2-phenylaminothiazolines from N-2-hydroxyethyl)-N′-phenylthioureas

TH Kim, JK Min, GJ Lee

Index: Kim, Taek Hyeon; Min, Jung Ki; Lee, Gue-Jae Tetrahedron Letters, 1999 , vol. 40, # 47 p. 8201 - 8204

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Citation Number: 15

Abstract

Synthesis of N-[(1,1-dimethyl-2-hydroxy)ethyl]-N′-phenylthiourea (2a): To a stirred solution of 2-amino-2-methyl-1- propanol 1a (0.44 mL, 4.59 mmol, 110 M%) in THF (10 mL) under nitrogen at room temperature was added a solution of phenyl isothiocyanate (0.50 mL, 4.18 mmol, 100