Evaluation of endo-and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

…, HM Armstrong, LL Chang, AF Cheng, L Colwell…

Index: Chu, Lin; Armstrong, Helen M.; Chang, Linda L.; Cheng, Amy F.; Colwell, Lawrence; Cui, Jisong; Evans, Jilly; Galka, Amy; Goulet, Mark T.; Hayes, Nancy; Lo, Jane; Menke, John; Ok, Hyun O.; Ondeyka, Debra L.; Patel, Minal; Quaker, Grace M.; Sings, Heather; Witkin, Stephanie L.; Zhao, Annie; Ujjainwalla, Feroze Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4133 - 4138

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Citation Number: 4

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. ... The investigation of endo and exo-aryl substitutions and the ...