e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis, x-ray crystal structure, and antimitotic properties of 6-chloro-2-methoxy-5-(2', 3', 4'-trimethoxyphenyl) cyclohepta-2, 4, 6-trien-1-one, a bicyclic analog of …
A regiocontrolled synthesis of the bicyclic colchicine analogue 2 has been achieved. Thus, the readily available cyclohexenone 10 was elaborated to the tricyclic compounds 15a, 16b, and 17b, which were converted into the a-methoxy enone 6. Reaction of 6 with 1, 8- diazabicyclo [5.4. 0] undec-7-ene gave the title compound (2). Subjection of diol 17b to a Swern reaction, using excess oxidant, afforded the free tropolone 22, which, on 0- ...
