Synthesis of Potential Anticancer Agents

CE Williamson, TJ Sayers, AM Seligman…

Index: Williamson,C.E. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 511

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Abstract

TLyo ticw secoiidai~ y iiitrogclii mustards, 2-cliloroei hyl-l. 3-dic. hIoi. o-2-propylaiiiiiie (I) aiid 1,; 2-dichloro-2-propylamiiie,(11), liitve beeii syiithesized aiid tested in trimor-bearing anirnals.: j Conipoiirid I eshibits greater anticancer activity atid less toxicity thaii bis (2- chloroet hy1) aniiiie (tior-IIN2) which has been widely en> ployed i ti cancer chetnolherapy research. These secondary amities were phosphorylated: id iricotporated iiito cc~ ...