Non-acidic anti-inflammatory compounds: activity of N-(4, 6-dimethyl-2-pyridinyl) benzamides and derivatives

S Robert-Piessard, G Le Baut, J Courant…

Index: Robert-Piessard, Sylvie; Le Baut, Guillaume; Courant, Jacqueline; Brion, Jean-Daniel; Sparfel, Louis; et al. European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 9 - 19

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Citation Number: 16

Abstract

Abstract The inhibition of the carragenin-induced rat-paw edema by previously synthesized N-(4, 6-dimethyl)-2-pyridinyl) benzamides was evaluated. Among the 29 tested compounds, secondary benzamides 1, 12 and tertiary benzamide 60 exhibited a significant anti- inflammatory activity. It prompted us to envision a pharmacomodulation in this series by structural modifications on the homocycle, the amide function and the heterocycle. ...