European journal of medicinal chemistry

Microwave supported synthesis of some novel 1, 3-Diarylpyrazino [1, 2-a] benzimidazole derivatives and investigation of their anticancer activities

S Demirayak, I Kayagil, L Yurttas

Index: Demirayak, Seref; Kayagil, Ismail; Yurttas, Leyla European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 411 - 416

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Citation Number: 73

Abstract

The syntheses of 1, 3-diarylpyrazino [1, 2-a] benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in acetone to give 1-(2-aryl-2-oxoethyl)-2- aryloylbenzimidazoles. The resulting materials were reacted with ammonium acetate in acetic acid to obtain the aimed compound. In this reaction, microwave irradiation method ...